Interstitial Cells of Cajal – Pacemakers of the Intestinal Musculature
نویسندگان
چکیده
The paper reviews the present-day knowledge on the origin, location, morphology, function, and identification of interstitial cells of Cajal (ICC). ICC include several types of mesenchymal cells, spindle-shaped or stellate, found within the musculature of the gastrointestinal tract. Some types of ICC act as pacemakers of the intestinal musculature, while others are implicated in the modulation of enteric neurotransmission. Current methods for ICC identification rely on a combination of ultrastructural characteristics as defined by transmission electron microscopy and immunohistochemical analyses with antibodies to the Kit receptor. ICC play a crucial role in the regular intestinal activity, which is the reason why changes in these cells may lead to various intestinal disorders.
منابع مشابه
The evaluation of interstitial Cajal cells distribution in non-tumoral colon disorders.
Interstitial cells of Cajal (ICC) are pacemakers that generate electric waves recorded from the gut and are important for intestinal motility. The aim of the study was to evaluate the distribution of interstitial cells of Cajal in colon specimens from patients with idiopathic chronic pseudo-obstruction and other non-tumoral colon disorders as compared with samples from normal colon. The distrib...
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